Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease
Identifieur interne : 000048 ( Main/Corpus ); précédent : 000047; suivant : 000049Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease
Auteurs : Bart Post ; Dino Muslimovic ; Nan Van Geloven ; Johannes D. Speelman ; Ben Schmand ; Rob J. De HaanSource :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
English descriptors
Abstract
Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23467
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title><author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name><affiliation><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Muslimovic, Dino" sort="Muslimovic, Dino" uniqKey="Muslimovic D" first="Dino" last="Muslimovic">Dino Muslimovic</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Geloven, Nan" sort="Van Geloven, Nan" uniqKey="Van Geloven N" first="Nan" last="Van Geloven">Nan Van Geloven</name><affiliation><mods:affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="De Haan, Rob J" sort="De Haan, Rob J" uniqKey="De Haan R" first="Rob J." last="De Haan">Rob J. De Haan</name><affiliation><mods:affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:47C967592FC8FB1AAC2BB5254412CB834E74D1D5</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23467</idno><idno type="url">https://api.istex.fr/document/47C967592FC8FB1AAC2BB5254412CB834E74D1D5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000048</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title><author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name><affiliation><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Muslimovic, Dino" sort="Muslimovic, Dino" uniqKey="Muslimovic D" first="Dino" last="Muslimovic">Dino Muslimovic</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Geloven, Nan" sort="Van Geloven, Nan" uniqKey="Van Geloven N" first="Nan" last="Van Geloven">Nan Van Geloven</name><affiliation><mods:affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="De Haan, Rob J" sort="De Haan, Rob J" uniqKey="De Haan R" first="Rob J." last="De Haan">Rob J. De Haan</name><affiliation><mods:affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="449">449</biblScope><biblScope unit="page" to="456">456</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">47C967592FC8FB1AAC2BB5254412CB834E74D1D5</idno><idno type="DOI">10.1002/mds.23467</idno><idno type="ArticleID">MDS23467</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>disability</term><term>motor impairment</term><term>prognosis</term><term>quality of life</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Bart Post MD, PhD</name><affiliations><json:string>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,The Netherlands</json:string></affiliations></json:item><json:item><name>Dino Muslimovic MSc, PhD</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Nan van Geloven MSc</name><affiliations><json:string>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Johannes D. Speelman MD, PhD</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Ben Schmand PhD</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Rob J. de Haan PhD</name><affiliations><json:string>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>motor impairment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>disability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>quality of life</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>prognosis</value></json:item></subject><articleId><json:string>MDS23467</json:string></articleId><language><json:string>eng</json:string></language><abstract>Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.548</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1830</abstractCharCount><pdfWordCount>4548</pdfWordCount><pdfCharCount>31950</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>264</abstractWordCount></qualityIndicators><title>Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title><corporate><json:item><name>on behalf of the CARPA‐study group</name></json:item></corporate><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>456</last><first>449</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23467</json:string></doi><id>47C967592FC8FB1AAC2BB5254412CB834E74D1D5</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/47C967592FC8FB1AAC2BB5254412CB834E74D1D5/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/47C967592FC8FB1AAC2BB5254412CB834E74D1D5/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/47C967592FC8FB1AAC2BB5254412CB834E74D1D5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title><author><orgName>on behalf of the CARPA‐study group</orgName></author><author><persName><forename type="first">Bart</forename><surname>Post</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands</p></note><affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,The Netherlands</affiliation></author><author><persName><forename type="first">Dino</forename><surname>Muslimovic</surname></persName><roleName type="degree">MSc, PhD</roleName><affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Nan</forename><surname>van Geloven</surname></persName><roleName type="degree">MSc</roleName><affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Johannes D.</forename><surname>Speelman</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Ben</forename><surname>Schmand</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Rob J.</forename><surname>de Haan</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="449">449</biblScope><biblScope unit="page" to="456">456</biblScope></imprint></monogr><idno type="istex">47C967592FC8FB1AAC2BB5254412CB834E74D1D5</idno><idno type="DOI">10.1002/mds.23467</idno><idno type="ArticleID">MDS23467</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>motor impairment</term></item><item><term>disability</term></item><item><term>quality of life</term></item><item><term>prognosis</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-12-01">Received</change><change when="2010-09-10">Registration</change><change when="2011-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/47C967592FC8FB1AAC2BB5254412CB834E74D1D5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Box 22660, 1100 DD Amsterdam, The Netherlands</correspondenceTo><objectNameGroup><objectName elementName="appendix">APPENDIX</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23467.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="8"></count><count type="referenceTotal" number="31"></count><count type="wordTotal" number="8432"></count></countGroup><titleGroup><title type="main" xml:lang="en">Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease<link href="#fn12"></link></title><title type="short" xml:lang="en">Progression and Prognostic Factors of PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Bart</givenNames><familyName>Post</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>b.post@amc.uva.nl</email><email>b.post@neuro.umcn.nl</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Dino</givenNames><familyName>Muslimovic</familyName><degrees>MSc, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Nan</givenNames><familyName>van Geloven</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Johannes D.</givenNames><familyName>Speelman</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Ben</givenNames><familyName>Schmand</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Rob J.</givenNames><familyName>de Haan</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3" noteRef="#fn13"><groupName>on behalf of the CARPA‐study group</groupName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NL" type="organization"><unparsedAffiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">motor impairment</keyword><keyword xml:id="kwd3">disability</keyword><keyword xml:id="kwd4">quality of life</keyword><keyword xml:id="kwd5">prognosis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Objective:</title><p>To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment.</p></section><section xml:id="abs1-4"><title type="main">Conclusions:</title><p>Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn12"><p><b>Relevant conflicts of interest/financial disclosures: Nothing to report.</b> Full financial disclosures and author roles may be found in the online version of this article.</p></note><note xml:id="fn13"><p>Members of the “CARPA‐study group” are listed in Appendix.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Progression and Prognostic Factors of PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Bart</namePart><namePart type="family">Post</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,The Netherlands</affiliation><description>Correspondence: Department of Neurology, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dino</namePart><namePart type="family">Muslimovic</namePart><namePart type="termsOfAddress">MSc, PhD</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nan</namePart><namePart type="family">van Geloven</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johannes D.</namePart><namePart type="family">Speelman</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ben</namePart><namePart type="family">Schmand</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rob J.</namePart><namePart type="family">de Haan</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on behalf of the CARPA‐study group</namePart><description>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,The NetherlandsDepartment of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-02-15</dateIssued><dateCaptured encoding="w3cdtf">2009-12-01</dateCaptured><dateValid encoding="w3cdtf">2010-09-10</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">8</extent><extent unit="references">31</extent><extent unit="words">8432</extent></physicalDescription><abstract lang="en">Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>motor impairment</topic><topic>disability</topic><topic>quality of life</topic><topic>prognosis</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>449</start><end>456</end><total>8</total></extent></part></relatedItem><identifier type="istex">47C967592FC8FB1AAC2BB5254412CB834E74D1D5</identifier><identifier type="DOI">10.1002/mds.23467</identifier><identifier type="ArticleID">MDS23467</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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